Alternatively, the drug molecule may be modified chemically by the syntheses of suitable prodrugs [10] or salt forms of the drug that often exhibit greater aqueous solubility than the parent molecule. ... Alternatively, a large tubular shaped milling chamber, circular or oblong, may be used, with colliding air jets at the periphery and the ...
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WhatsApp: +86 18203695377The suspension is pumped back into the milling chamber with a certain velocity and hence within a short residence time in the chamber, the particles are exposed to high energy input thereby reducing its particle size (Kwade, 1999). Planetary ball mills with modified sample holders are available for smallscale production of nanosuspension.
WhatsApp: +86 18203695377The milling chamber is charged with milling media. A crude slurry consisting of drug, water and stabilizer is fed into the milling chamber and processed into a nanocrystalline dispersion. Source ...
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WhatsApp: +86 18203695377The resulting suspensions (10% drug content) were wet milled at 400 rpm in the milling chamber (50 mL) of a planetary ball mill (PM 100 MA, Retsch , Haan, Germany). The milling balls were mm ZrO 2 beads. As a preliminary experiment, the effects of different pearl weights (10, 20, 50 and 150 g) on the particle size reduction were ...
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